I have read that autoimmunity happens when the immune system overreacts to a pathogen (see General Pathophysiology). But I think the immune system is doing what it is designed to do. It tries to communicate with the cell to see if it is “self” but the cannot respond for some reason. One hypothesis is that our cells get coated with toxins that the body cannot dispose of. That somehow block it’s ability to respond . With age and loss of hormones some woman like myself get diagnosed with primary biliary cirrhosis or it is now called something else. Somehow estrogen protects. I wonder if there is a way to understand what is going on when autoimmunity is triggered.